Aarkstore Enterprise -Advances in nanotechnology – Innovations in Oral Solid Drug Delivery: controlled formulations & peptide delivery-Aarkstore E
Aarkstore Enterprise -Advances in nanotechnology – Innovations in Oral Solid Drug Delivery: controlled formulations & peptide delivery-Aarkstore E
Innovations in Oral Solid Drug Delivery: Advances in nanotechnology, controlled formulations & peptide delivery
Table of Contents :
Innovations in oral solid drug delivery
Executive summary 18
Market overview, dynamics and outlook 18
Advances in nanotechnology 19
Innovations in transitioning injectables to oral delivery 20
Advances in delayed & controlled release delivery 21
Advances in oral prodrug delivery 22
Advances in taste masking technologies 23
Innovative companies 24
Chapter 1 Market overview, dynamics and outlook 28
Summary 28
Market overview 29
Market dynamics 31
Key indications 33
Key trends 38
Nanomedicine 38
Transitioning from injectables 39
Prodrugs 40
Chrono release 41
ODT 41
OSF 42
Funding issues 42
Poor patient compliance 42
Injections 42
Poor absorbption 42
Pediatric 43
Geriatric 43
Solubility and variable absorption 43
Reduction of side effect profiles 44
Non-invasive protein delivery 45
Transition from injectables to preferred route of oral drug delivery 45
Directed delivery and delayed delivery to reduce side effect potential 46
Formulation technologies for poorly soluble compounds 46
Taste masking for pediatric and geriatric formulations 47
Competitive landscape 48
Conclusions and key findings 50
Chapter 2 Advances in nanotechnology 56
Summary 56
Introduction 57
Nanotechnology platforms with application for oral drug delivery 59
Self-Emulsifying Controlled Release Tablet system (SECRET) 59
Technology 59
Application 59
Biotransport nanomedicine technology 60
Technology 60
Application 60
Nanobodies 61
Technology 61
Application 61
NanoDel nanoparticles 62
Technology 62
Application 62
P-gpMask 63
Technology 63
Application 64
NanoDRY and NanoCOAT 64
Technology 64
Application 64
Solumer 67
Technology 67
Application 67
Nanocells 69
Technology 69
Application 70
Polymeric Nano-Delivery System (PNDS) 70
Technology 70
Application 71
FluidCrystal NP Oral nanoparticles 71
Technology 71
Application 72
CaP Technology and BioOral 72
Technology 72
Application 73
Nab Technology and Protospheres 73
Technology 73
Application 73
NanoCrystal Technology 74
Technology 74
Application 74
Bioral 75
Technology 75
Application 75
Squalenoyl nanoparticles 76
NanoMega 76
NOD Pharmaceutical 76
Chapter 3 Innovations in transitioning injectables to oral delivery 80
Summary 80
Introduction 81
Drivers 81
Patient acceptability & compliance 81
Cost savings 81
Restraints 82
Advances in injectable delivery 82
Challenges of oral drug delivery 83
Technologies used in oral drug delivery of peptides and proteins 84
Enzyme inhibitors 84
Permeation enhancers 85
Mucoadhesives 85
Encapsulation technologies 85
M-cell targeting 86
Competitive landscape 86
Osteoporosis and other bone related conditions 88
Calcitonin 88
Current therapies & market landscape 89
Oral products in development 91
Parathyroid hormone 94
Current therapies & market landscape 94
Oral products in development 96
Combined oral calcitonin and PTH approaches 97
Bisphosphonates 97
Current therapies & market landscape 97
Novel oral products in development 99
Diabetes and other metabolic diseases 104
Oral insulin 104
Oramed Pharmaceuticals 104
Biocon Ltd 105
Emisphere Technologies 105
Diabetology 106
NOD Pharmaceuticals 106
Access Pharmaceuticals 107
NanoMega Medical Corporation 107
Biodel Inc 108
Metabolic Pharmaceuticals Ltd
Aarkstore Enterprise -Worldwide Nanotechnology Dental Implant Market Shares, Strategies, Forecasts, Aarkstore Enterprise -
Aarkstore Enterprise -Worldwide Nanotechnology Dental Implant Market Shares, Strategies, Forecasts, Aarkstore Enterprise -
Worldwide Nanotechnology Dental Implant Market Shares, Strategies, and Forecasts, 2009 to 2015
Table of Contents :
Dental Implant Executive Summary ES-1
Global Dental Implant Market ES-1
Nanotechnology Impacts The Dental Implant Market ES-3
Dental Implant Market Driving Forces ES-4
Innovation Drives Dental Implant Markets ES-9
Dental Implant Market Trends ES-9
Aging of the Population ES-11
Dental Implant Market Shares ES-11
Dental Implant Market Forecasts ES-13
Dental Implant Market Forecasts Reflect Uncertainty
In The Global Economy ES-15
1. Dental Implant Market Description and Market Dynamics 1-1
1.1 Dental Implant Definition 1-1
1.1.1 American Dental Association Recommended
Types Of Dental Implants 1-2
1.1.2 Dental Implant Longevity 1-2
1.1.3 Types of Dental Implants 1-4
1.1.4 Titanium Dental Implants 1-4
1.1.5 Root-Form Dental Implant 1-4
1.1.6 Ramus-Frame Dental Implant 1-5
1.1.7 Transosseous Dental Implant 1-5
1.1.8 Blade-Form Dental Implant 1-6
1.1.9 Types of Dental Implant Devices 1-6
1.2 Dental Implants Require Follow-Up Treatment 1-8
1.2.1 Poor Oral Health And Tooth Loss Associated
With Serious Health Problems 1-9
1.2.2 Dental Implant Target Markets 1-10
1.3 Dental Implants 1-10
1.3.1 Small-Diameter Dental Implants
Increasingly Popular In the US 1-11
1.3.2 Clinical Research on Osseo-integrated Dental Implants 1-11
1.3.3 Osseo-Integrated Dental Implants Placed In Bone 1-12
1.3.4 Success Of Implants Attributed To Osseo-Integration 1-12
1.3.5 Implant Failure Higher In Smokers 1-13
1.3.6 Proactive, Integrated, And Patient Centric Solutions 1-13
2. Dental Implant Market Shares and Market Forecasts 2-1
2.1 Dental Implant Market Driving Forces 2-1
2.1.1 Innovation Drives Dental Implant Markets 2-5
2.1.2 Dental Implant Market Trends 2-5
2.2 Aging of the Population 2-7
2.3 Dental Implant Market Shares 2-11
2.3.1 Nobel Biocare 2-14
2.3.2 Straumann 2-19
2.3.3 OpenCell BioMed (OCBM) 2-26
2.3.4 Zimmer 2-26
2.3.5 Zimmer Tapered Screw-Vent Implant 2-28
2.3.6 Astra Tech 2-28
2.3.7 Astra Tech Implant System 2-29
2.3.8 Biomet 3i NanoTite™ Surface 2-29
2.3.9 Dentsply 2-30
2.3.10 Dentsply Frialit Plus Surface Implants –
Prevention Instead Of Intervention For Esthetics 2-31
2.4 Dental Implant Market Forecasts 2-32
2.4.1 Dental Implant Market Forecasts Reflect
Uncertainty In The Global Economy 2-33
2.4.2 Dental CAD/CAM Shipments 2-37
2.4.3 Dental Regenerative Materials Market Forecasts 2-39
2.4.4 Dental Implant, CAD/CAM, Regenerative
Dentistry Shipments, Forecasts 2-40
2.4.5 Digital Dentistry 2-45
2.4.6 Small Diameter Dental Implant Forecasts 2-46
2.5 Implant Porous Coatings 2-46
2.5.1 Orchid Orthopedic Solutions 2-46
2.6 Number of Root Canals 2-47
2.7 Dental Implant Return on Investment ROI Analysis 2-47
2.8 Dental Implant Regional Analysis 2-49
2.8.1 AstraTech in Japan 2-52
2.8.2 Dentsply Dental Implant Regional Positioning 2-53
2.8.3 Dentsply in the United States 2-54
2.8.4 Dentsply Europe 2-54
2.8.5 Dentsply All Other Regions 2-55
2.8.6 Nobel Biocare in Europe, Middle East and Africa 2-55
2.8.7 Nobel Biocare in North America 2-55
2.8.8 Nobel Biocare in Asia 2-55
3. Dental Implant Product Description 3-1
3.1 Nobel Biocare 3-1
3.1.1 Nobel Biocare NobelActive™ Dental Implant 3-4
3.1.2 Nobel Biocare NobelReplace™ Dental Prosthetic Flexibility 3-8
3.1.3 Nobel Biocare / ISI (Imaging Sciences International)
Treatment Planning Software Partnership 3-10
3.1.4 Nobel Biocare Digital Dentistry 3-10
3.1.5 Nobel Biocare Small Diameter Implants And
Orthodontic Mini Screws 3-24
Worldwide Nanotechnology Dental Implant Market Shares, Strategies, And Forecasts, 2009 To 2015-Aarkstore Enterprise
Worldwide Nanotechnology Dental Implant Market Shares, Strategies, And Forecasts, 2009 To 2015-Aarkstore Enterprise
Worldwide dental implants are poised to achieve significant growth as patients become aware of the health benefits achieved from having viable teeth. Dental implants are in the category of optional surgery and represent the type of consumer spending that is postponed in challenging economic environments.
The companies participating in the dental implant market have found ways to manage infection, providing a higher implant success rate. Implantable devices are more stable in the mouth, permitting fewer dental implant failures. 69% of adults ages 35 to 44 have lost at least one permanent tooth to an accident, gum disease, a failed root canal, or tooth decay. By age 74, 26% of adults have lost all of their permanent teeth. With the number of Americans over 55 growing by 60% in the next 20 years there is plenty of U.S. market opportunity. The baby boomer generation buying power exceeds trillion in 2009.
The leading six dental implant manufacturers control of the market is based on the need for marketing in this segment, with Nobel Biocare holding the number one market position and Straumann holding a share of almost one-fifth and ranking as the firm number-two player. A large number of small manufacturers earlier accounting for a third of the market have shrunk to 14% of it.
Dental implant market innovations are those that position the vendor companies to meet aesthetic demands and increase clinician productivity. Positioning for profitable business patient care delivery can be challenging for clinicians. Tooth loss, gum and bone disease affect millions of people worldwide, on every continent, in every age group. Globally, several hundred million people are missing one or more teeth. More than 40 million people are fully edentulous in the Western developed world. These numbers are substantially higher in Asia, Africa and other parts of the world.
Worldwide, weaknesses in the global economy and sagging consumer confidence have led to an unprecedented slowdown in the dental market. Reduced income has kept many patients away from the dentist. People with steady incomes fear losing their jobs and are not spending even if they can afford to. Elective procedures are being postponed.
General practitioners are tending to treat patients in house with conventional alternative treatments, rather than referring them for implant treatment, despite its superiority. Customers are reducing stocks. Dental labs are more hesitant to invest in dental equipment, such as CAD/CAM scanners.
Dental implant market innovations are those that position the vendor companies to meet aesthetic demands and increase clinician productivity. Positioning for profitable business patient care delivery can be challenging for clinicians. Tooth loss, gum and bone disease affect millions of people worldwide, on every continent, in every age group. Globally, several hundred million people are missing one or more teeth. More than 40 million people are fully edentulous in the Western developed world. These numbers are substantially higher in Asia, Africa and other parts of the world.
For 2008 the global dental implant market was 2.3 billion Euros. The market for crowns and bridges is 3 billion Euros. These estimates size the opportunity of the global restorative and esthetic dentistry market. Nobel Biocare is the clear market leader in this market.
The outlook for 2009 is one of a demanding market environment. Deteriorating economic conditions in most markets continue to impact dental implant markets because consumers have less discretionary income. Visibility in economic recovery time remains low.
Nanotechnology Impacts The Dental Implant Market One of the most active and important current areas of research and application of nanotechnology is in the field of life sciences and healthcare. Many industry and business analysts now expect nanotechnology to
Global Nanotechnology Market for Energy Storage – Analysis and Forecasts to 2015—Aarkstore Enterprise Market Research Aggregation
Global Nanotechnology Market for Energy Storage – Analysis and Forecasts to 2015—Aarkstore Enterprise Market Research Aggregation
Summary
New report, Global Nanotechnology Markets for Energy Storage – Analysis and Forecasts to 2015″, provides key data, information and analysis on the market opportunities in the nanotechnology enabled energy storage market. The report provides key market trends and competitive landscape analysis for the market. The research discusses market dynamics in detail by providing analytical content on the key challenges for the commercialization of nanotechnology. The report’s coverage of the nanotechnology enabled energy storage market is comprehensive with dedicated sections on the state of research, patent analysis, and key supplier profiles.
Scope
– Qualitative analysis of market drivers, restraints, future outlook, and challenges for the global nano-based energy storage market.
– Comprehensive coverage of R&D initiatives in nanotechnology for energy storage products.
– Competitive landscape section that provides company share information for 2008. Key players covered include Altair Nanotechnologies Inc, Valence Technology Inc., mPhase Technologies Inc., Nanoexa, Inc., and Maxwell Technologies Inc.
– Market sizing (revenue) forecasts for the lithium ion and ultracapacitors market from 2009 to 2015
– Key topics covered include nanotechnology enabled batteries, the ultracapacitor market potential, the state of research, and patent activities analysis.
Reasons to buy
- Gain most up to date information and analysis on the potential opportunities and challenges in the Global Nanotechnology Markets for Energy Efficiency and Energy Storage
- Identify growth segments and opportunities in the Global Nanotechnology Markets for Energy Efficiency and Energy Storage
- Facilitate decision-making based on strong historic and forecast data, deal analysis and recent developments
- Drive business decisions based on the analysis of key players and their market share
- Develop strategies based on the latest operational and regulatory events in the world
- Understand potential market opportunities in various geographies and fine tune your business strategy
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Here you can see wow Nanotechnology Works
Worldwide Nanotechnology Portable Fuel Cell Market Shares, Strategies, And Forecasts, 2009-2015-Aarkstore Enterprise
Worldwide Nanotechnology Portable Fuel Cell Market Shares, Strategies, And Forecasts, 2009-2015-Aarkstore Enterprise
Portable fuel cells are poised to achieve significant growth as units become smaller and fuels less expensive. According to Susan Eustis, lead author of the study, “Economies of scale do not entirely solve the inherent high costs of high grade metallic catalysts used in micro fuel cells. Nanotechnology is poised to provide new ways to create advanced materials that can be used to implement portable fuel cells. More catalyst price reductions are needed to make portable fuel cells competitive with thin film batteries. Portable fuel cells are useful in cities to power bicycles and for advanced multimedia electronics that draws a lot of power.”
Most of the developing world, where energy and environmental problems abound, still gets around on 2 wheels. 2% of the 1.5 billion population in China owns a car. Cities have started banning the use of 2-stroke engine motorcycles in favor of LPG scooters and electric bicycles.
19 million electric bicycles were purchased in 2008. The trend is expected to continue. As more people need to travel further each year, fuel cells take on a role in short distance travel. As economies evolve, fuel cells provide a role for green energy. Purchasing power constraints and air pollution issues stimulate the need for low cost, zero carbon transportation solutions.
Portable fuel cell vendors are strategically positioned to develop and implement solutions. Technology costs continue to decrease. Practical fuel solutions continue to develop. Experiments with portable fuel cell products are starting to take place in various parts of the world.
Nanotechnology is being used to implement a variety of portable fuel cell solutions. Many different nanotechnology techniques are being explored. One is of a silicon structure, approximately 400 microns deep, much thicker than the 10-micron depth of a membrane in a traditional PEM-based cell. This design is expected to enable a much larger reaction surface area, enabling high power in a small form-factor.
To compress more power into smaller volumes, researchers have begun to build fuel cells on the fuzzy frontier of nanotechnology. Silicon etching, evaporation, and other processes borrowed from chip manufacturers have been used to create tightly packed channel arrays to guide the flow of fuel through the cell.
The point is to pack a large catalytic surface area into a wafer-thin volume. This approach is evolving, going beyond two-dimensional aspects to gain more surface area. Methods improve the performance of nano-scale fuel cells.
Three-dimensional structures improve current electrocatalysts that have traditionally been expressed on a flat surface. Two dimensional catalysts give hundreds of microamps per square centimeter, while three dimensional catalysts increase the surface area by orders of magnitude.
Fuel channels are evolving in ready-made in a commonly available, porous alumina filters costing only about . The filter is riddled with neat, cylindrical holes only 200 nanometers in diameter, and was initially used in labs as a template for the growth of nanowires.
Nanowires can be grown in a platinum-copper alloy, then dissolving the copper by soaking the filter in nitric acid creates electrodes. In place of a solid nanowire, each hole is left with a porous platinum electrode. The partially dissolved wires are structurally complex, as befits their random nature, and have an enormous surface area for their size.
The market size for portable fuel cell power at .1 million in 2008 is estimated to reach .4 billion dollars by 2015. Existing markets are from mobile homes and PCs used remotely. Strong growth comes as hybrid fuel cell systems evolve to support thin film batteries. The fuel will come from renewable energy sources.
Table of Contents :
NANOTECHNOLOGY PORTABLE FUEL CELL MARKET SHARES AND MARKET FORECASTS
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