New Generation Reproductive Technologies (stem Cell-nanotechnology)

New Generation Reproductive Technologies (stem Cell-nanotechnology)

I. Advances in Embryonic and Placental Development

1.Abstract:

Early embryonic development needs detailed investigations if we have to reduce embryonic mortality. Embryonic mortality details have been reviewed (wani, 2005). The reproductive abnormalities have been discussed and a sequential photographic presentation of embryonic mortality have recently been published (Khatoon et al 2007). The critical period when maximum embryonic losses go unnoticed is the period before attachment. Losses before actual union of foeto-maternal tissues can be missed and calculations of embryonic mortality estimates remain unaccounted for. Some recent studies of (Wani 2006, Khatoon et al 2006) have paved a new innovative model for investigation on foeto-maternal development and its attachment. This paper describes the detailed embryonic development, blastocyst elongation, formation of cotyledons within elongated blastocyst, their ramifications and networking of vasculature and formation of foetal placental unit. Conversely, a detailed photographic evidence of uterine receptivity, formation of a multicoated immunological barrier- the beginning of foeto- maternal- barrier mechanism along with caruncle formation, uterine milk formation and finally union of cotyledous with caruncles has been photographically documented.
2.Introduction:

Second and 3rd generation animal biotechnologies as reviewed (Wani, 2005) are multiple ovulation, embryo-transfer, preservation, cloning, micromanipulation splitting of embryos and nuclear transfer. The 4th Generation reproductive technologies have advance beyond our imagination and now we do have transgenic goats giving milk rich in insulin. (Wani 2007). The stem cell technology, embryonic cell culture, pronuclear micro-injection along with sperm-mediated, transgenesis have been in use and are precisely reviewed and discussed (Wani 2005, 2007).

The application of this advancement for diagnostic, therapeutic and economic uses especially its transfer to human medicine or for field application in animal industry needs further research and evaluation.

The another fact which can be of importance is the number of cells per embryos. During first day these may be two cells but after 8 days the cell number increases to 120 or more. It takes 32 hours for the oocyst after fertilization to reach the two cell embryo. Another 13 hours are needed to develop it into a four cell embryo. In another 15 hours 8 cell stages is reached. It is from here onwards that it takes 30 hours for a embryo to be converted into a Morula. This has been one of the most critical periods of embryonic development in ovine. A genematic diagram of various stages of follical maturation of oocytes development and further development has been reported (Wani 2005a) figure from web site is also show that the protein content after fertilization of 16 day old embryo increased by 7500 times. Morphologically the embryo size varies from spherical ovid to elongate after day 13th past coitus. New protein synthesis per unit of embryo is maximum during 8-13th day old embryos. Similarly phosphorylation per unit of embryo is also ten times more in 8 day old embryos than the later stages. Glucose and lactose production increased up to day 16th and the maximum metabolic weight is up to 14th day past coitus. For increased productive synthesis, aminoacid requirements are made, through production of allanic and glutonic acids by the embryos. The matobolic products get rid of amines. The signal transduction from maternal to foetal controls have been discussed (Moris et al 2001).
3. Dominant follicle dynamics

The new animal , products, medico-Veterinary packages, profitable genetic (trait) improved DNA Chips, more resistance

Study Uncovers Mesothelioma Link to Nanotechnology

Study Uncovers Mesothelioma Link to Nanotechnology

Mesothelioma has long been linked to the inhalation and exposure to asbestos fibers and dust, so when scientists uncovered an additional potential cause for this incurable form of lung cancer, the unthinkable became a reality.

According to researchers based out of the Woodrow Wilson International Centre for Scholars in Washington D.C., the early 90′s development of carbon nanotubes has been an amazing feat for technological applications, however, it has not gone without its price. Specifically, carbon nanotubes may be causing harm to the human body in the form of mesothelioma cancer.

If the carbon nanotubes are introduced into the wrong environment, the development of lesions and inflammation of the lungs occurs – symptoms similar to that of mesothelioma cancer and asbestos exposure. Researchers uncovered the finding through exposure of carbon nanotubes to animals.

Dr. Andrew Maynard, who published a study in the journal Nature Nanotechnology, described the use of nanotubes and the potential link to mesothelioma cancer. He said that currently, nanotubes are being implemented because of their awesome abilities at conducting heat and electricity. Mostly, Dr. Maynard explains, the nanotubes are being implemented into sports equipment. He said that there are no regulations as to where nanotubes can be implemented and there are currently no requirements for the use of nanotubes to be disclosed to the general public.

What Are Nanotubes?

According to Maynard, nanotubes are a product of nanotechnology research, one he considers the “poster child” of nanotechnology. The nanotubes are cylindrical structures comprised of carbon atoms that have been rolled together. Maynard’s study found that when mice were exposed to nanotubes, they developed asbestos-induced symptoms within the lungs. While he and other researchers consider nanotubes to be safe – when encased – the risk occurs when nanotubes are incinerated or broken.

Nanotubes are currently being used in:

* a variety of sports equipment

* bicycle frames

* tennis rackets

* electronic gas detectors

* radios

Additionally, because of the strength of nanotubes, many consider its future use to vastly effect several business ventures and areas, and be widely used in industries including:

* aerospace

* automobile

* airplanes

* television box productions

* medical

* environmental uses

Working with Nanotubes

While the National Institute for Occupational Safety and Health (NIOSH) is doing research on nanotoxicology, there is little knowledge or research currently available regarding the safety of using nanotechnology. Additionally, Dr. Maynard noted that because of the ever-increasing nanotechnology industry, which is likely to be worth .6 trillion by 2014, it will be difficult to adequately and accurately assess nanotechnology safety because of the technology’s quick growth, which is also being used in the food industry.

Transparency of nanotoxicology among some nanotechnologically-produced products may fall into the hands of manufacturers and producers, which John M. Balbus, health program chief for the Environmental Defense Fund who was interviewed in a Washington Post article on nanotechnology, said could either be a very good thing with open communications, or a very bad thing replicating the mistakes made among the construction industry’s use of asbestos. However, he noted that upfront communication regarding the dangers of nanotechnology with the public may increase because of the previous mistakes made by other industries in hiding mesothelioma conditions from the public.

Finding Help with Nanotube

Nanotechnology – Revolution in the Field of Medicine

Nanotechnology – Revolution in the Field of Medicine

In the recent years, there has been a tremendous development in the field of nanotechnology. Nanotechnology is a field of applied science, which deals in building machines and bots at microscopic levels. Due to development in nanotechnology, there have been many developments in various fields of science, especially in the field of medicine.

 

With the help of nanotechnology, carrying out a complex heart surgery is very much possible. Doctors have started making use of nanobots to cure certain diseases. These nanobots also help in rectifying certain disorders in the human body.

 

Nanotechnology in Drug Development:

 

Recently, scientists are developing effective and better drug delivery systems using nanotechnology. Scientists are using nanoparticles to design a drug delivery system that may improve the pharmaceutical and therapeutic properties of a drug and help better processes such as Drug screening. Nanaoparticles have remarkable properties that drastically enhance the drug delivery. Due to their microscopic sizes, nanoparticles get an easy access in the cells.

 

There are numerous developments in the drug delivery owing to nanotechnology. One such development using nanotechnology is the transfer of drugs into the cytoplasm of cells through the cell membrane. This is an important development, because to hinder certain diseases from the body, the drug needs to enter the cell membrane.

 

 To make a drug molecule effective in the body, it needs a triggered response. To do so, scientists are using nanotechnology. Scientists are developing drugs using nanotechnology that automatically activate, once they enter the human body.

 

Many researchers believe that it is possible to develop a drug delivery system that may prove beneficial in treating cancer and infectious diseases using nanotechnology. By far, they have identified six types of nano-enabled delivery systems that have considerable potential in treating cancer and other infectious diseases.

 

With the help of nanotechnology, scientists have developed injectable drugs, which are more pleasing for the patients, who receive them and at the same time are easy to administer. Better opportunities are coming up in the development of implantable delivery systems, due to the use of nanotechnology, especially in terms of injectable drugs. 

 

With so much of development taking place in the field of drug delivery systems, researchers believe that in the near future nano-enabled medicines will have a tremendous evolution and will produce true nanomedicines.

More Nanotechnology Articles

Nanotechnology – Revolution in the Field of Medicine

Nanotechnology – Revolution in the Field of Medicine

In the recent years, there has been a tremendous development in the field of nanotechnology. Nanotechnology is a field of applied science, which deals in building machines and bots at microscopic levels. Due to development in nanotechnology, there have been many developments in various fields of science, especially in the field of medicine.

 

With the help of nanotechnology, carrying out a complex heart surgery is very much possible. Doctors have started making use of nanobots to cure certain diseases. These nanobots also help in rectifying certain disorders in the human body.

 

Nanotechnology in Drug Development:

 

Recently, scientists are developing effective and better drug delivery systems using nanotechnology. Scientists are using nanoparticles to design a drug delivery system that may improve the pharmaceutical and therapeutic properties of a drug and help better processes such as Drug screening. Nanaoparticles have remarkable properties that drastically enhance the drug delivery. Due to their microscopic sizes, nanoparticles get an easy access in the cells.

 

There are numerous developments in the drug delivery owing to nanotechnology. One such development using nanotechnology is the transfer of drugs into the cytoplasm of cells through the cell membrane. This is an important development, because to hinder certain diseases from the body, the drug needs to enter the cell membrane.

 

 To make a drug molecule effective in the body, it needs a triggered response. To do so, scientists are using nanotechnology. Scientists are developing drugs using nanotechnology that automatically activate, once they enter the human body.

 

Many researchers believe that it is possible to develop a drug delivery system that may prove beneficial in treating cancer and infectious diseases using nanotechnology. By far, they have identified six types of nano-enabled delivery systems that have considerable potential in treating cancer and other infectious diseases.

 

With the help of nanotechnology, scientists have developed injectable drugs, which are more pleasing for the patients, who receive them and at the same time are easy to administer. Better opportunities are coming up in the development of implantable delivery systems, due to the use of nanotechnology, especially in terms of injectable drugs. 

 

With so much of development taking place in the field of drug delivery systems, researchers believe that in the near future nano-enabled medicines will have a tremendous evolution and will produce true nanomedicines.

Nanotechnology: Giving a New Dimension to Food Industry

Nanotechnology: Giving a New Dimension to Food Industry

Nanotechnology: Giving a new dimension to Food Industry

INTRODUCTION:

A derivative of chemistry, engineering, and physics, and micro fabrication techniques, nanotechnology involves manipulating matter at the nanoscale level. It is responsible for determining not only that biological and nonbiological structures measuring less than 100 nm exist but also that they have unique and novel functional applications. In fact, the National Nanotechnology Initiative (NNI, 2006) defines nanotechnology as “the understanding and control of matter at dimensions of roughly 1 to 100 nanometers, where unique phenomena enable novel applications.” Because applications with structural features on the nanoscale level have physical, chemical, and biological properties that are substantially different from their macroscopic counterparts, nanotechnology can be beneficial on various levels. Research in biology, chemistry, engineering, and physics drives the development and exploration of the nanotechnology field. Consequently, certain industries such as microelectronics, aerospace, and pharmaceuticals have already begun manufacturing commercial products of nanoscale size. Even though the food industry is just beginning to explore its applications, nanotechnology exhibits great potential. Food undergoes a variety of postharvest and processing-induced modifications that affect its biological and biochemical makeup, so nanotechnology developments in the fields of biology and biochemistry could eventually also influence the food industry. Ideally, systems with structural features in the nanometer length range could affect aspects from food safety to molecular synthesis.

Potential Food Applications:

All organisms represent a consolidation of various nanoscale-size objects. Atoms and molecules combine to form dynamic structures and systems that are the building blocks of every organism’s existence. For humans, cell membranes, hormones, and DNA are examples of vital structures that measure in the nanometer range. In fact, every living organism on earth exists because of the presence and interaction of various nanostructures. Even food molecules such as carbohydrates, proteins, and fats are the results of nanoscale- level mergers between

sugars, amino acids, and fatty acids. As it applies to the food industry, nanotechnology involves using biological molecules such as sugars or proteins as target-recognition groups for nanostructures that could be used, for example, as biosensors on foods. Such biosensors could serve as detectors of food pathogens and other contaminants and as devices to track food products. Nanotechnology may also be useful in encapsulation systems for protection against environmental factors. In addition, it can be used in the design of food ingredients such as flavors and antioxidants. The goal is to improve the functionality of such ingredients while minimizing their concentration. As the infusion of novel ingredients into foods gains popularity, greater exploration of delivery and controlled-release systems for nutraceuticals will occur. Although nanotechnology can potentially be useful in all areas of food production and processing, many of the methods are either too expensive or too impractical to implement on a commercial scale. For this reason, nanoscale techniques are most cost-effective in the following areas of the food industry: development of new functional materials, food formulations, food processing at microscale and nanoscale levels, product development, and storage.

Nanodispersions and Nanocapsules:

As the fundamental components of foods, functional ingredients such as vitamins, antimicrobials, antioxidants, flavorings, and preservatives come in